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When compared with injectable GLP-1 agonists, orforglipron's discontinuation rates are broadly similar

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The guy who got metformin approved by the FDA says that metformin only has effects on the liver

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Interestingly, adult mice with modest isolated elevations in GH and IGF-1 levels have greater lean mass, improved lipid oxidation and glucose clearance 38 , while specific, temporal reductions in GH and IGF-1 in adults have been linked to deleterious metabolic effects, including impaired hepatic insulin action 38 , and reduced -cell mass and function 39

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